CROSS is an acronym for Cancer Research of the Oesophagus and Stomach at St James’s Hospital.

The charity is a focal point for cancer research that is undertaken at the Institute of Molecular Medicine located in the Trinity (College) Centre at the Hospital.

A significant element of the research programme relates to prevention and treatment of oesophageal and stomach cancer, but the Centre also undertakes research in cancer of the breast, colon, rectum and lung.


Molecular Research in The Department of Surgery

Molecular cancer research is best carried out by a critical mass of high quality biomolecular and biomedical researchers closely affiliated to clinical centres of excellence. This structure has been employed at the Institute of Molecular Medicine at St. James’s Hospital, where a molecular research team has been established under the Dept. Surgery in Cancer translational research laboratories.

The group have a strong interest in the molecular processes regulating the progression to oesophageal cancer. Other cancer types are also being investigated, including lung, colon and breast cancer. There is a particular focus on mechanisms regulating tumour growth in relation to obesity, metabolic syndrome and bioactive lipids. In addition, genomic and proteomic profiling studies are underway, to determine molecular signatures associated with response to treatment of patients undergoing multimodal chemo-radiation therapy.